ভেরোরাব র‍্যাবিস

Rabies vaccine is an inactivated virus vaccine that is used for active immunisation against rabies. It can be used for pre- and post-exposure immunisation. For post-exposure immunisation, it is often used in conjunction with rabies immunoglobulins as it takes about 7-10 days for the specific antibodies to develop.

ব্যবহার

র‍্যাবিস ভ্যাকসিনকে জলাতঙ্ক প্রতিরোধের প্রতিরোধী টিকা এবং সন্দেহজনক জলাতঙ্ক রোগীদের চিকিৎসার জন্য নির্দেশিত হয়। প্রাক-এক্সপোজার টিকাদান: পেশাদার গ্রুপগুলি ঘন ঘন দূষণের সংস্পর্শে আসে ভেটেরিনারি সার্জন (ভেটেরিনারি কলেজের শিক্ষার্থী সহ) প্রযুক্তিগত কর্মীরা ভেটেরিনারি সার্জনদের সাথে কাজ করছেন ল্যাবরেটরি কর্মীরা রেবিজ ভিএমএস দিয়ে দূষিত পদার্থের পরিচালনা করছেন অ্যাবটোয়ারস এবং ন্যাকার্স ইয়ার্ডে কর্মী Taxidermists এনজুটিক অঞ্চলে গেমকিপার, বনজ কর্মী এবং প্রকৃতিবিদ শিশুরা বিশেষত জলাতঙ্কের ঝুঁকির মুখোমুখি হয় এক্সপোজার পরবর্তী টিকা: অভদ্র প্রাণী বা প্রজাতির যেহেতু সন্দেহ হয়, তাদের দ্বারা কামড়ানো চিকিৎসা এর জন্য ব্যবহার করা হয় ।

ভেরোরাব র‍্যাবিস এর দাম কত? ভেরোরাব র‍্যাবিস এর দাম

সুচিপত্র

• ভেরোরাব র‍্যাবিস
• কাজ
• খাওয়ার নিয়ম
• পার্শ্বপ্রতিক্রিয়া
• সতর্কতা
• মিথস্ক্রিয়া
• গর্ভাবস্থাকালীন ব্যবহার
• তীব্র ওভারডোজ
• অন্যান্য ওষুধের সাথে প্রতিক্রিয়া
• বৈপরীত্য
• সংরক্ষণ

খাওয়ার নিয়ম / ব্যবহারের নিয়ম

ভেরোরাব র‍্যাবিস খাওয়ার নিয়ম / ব্যবহারের নিয়ম

To reconstitute the vaccine, transfer content of supplied diluent into the vial containing freeze-dried preparation. Do not shake. After reconstitution the solution should be homogeneous, clear and free from any particles. Vaccine must be injected immediately after reconstitution and the syringe should be destroyed after use.

Method of administration for intramuscular use: The 1ml dose of Rabies vaccine should be given intramuscularly in the deltoid in adults and in the anterolateral aspect of the thigh muscle in children under 1 year. It should not be injected into the gluteal region. Do not inject intravenously.

Method of administration for intradermal use: The 0.1 ml dose of Rabies vaccine (per site) should be administered intradenmally in the upper arm, over the deltoid.

Pre-exposure immunization: 1 ml for children and adults.

Primary-vaccination: According to the WHO recommendations 1 injection by the intramuscular route on days DO, D7, D21 or D28, followed by a booster dose one year later.

Boosters: Thereafter, one injection every 5 years or when the titre is found to be less than 0.5 lU/ml

Post-exposure immunization:

• Local treatment of the wound
• Vaccination of non-immunized subjects

Intramuscular schedules

: One Intramuscular (IM) dose comprised of 1 ml. Standard intramuscular (1-1-1-1-1) regimen:

• Day 0: 1 injection of 1 ml
• Day 3: 1 injection of 1 ml
• Day 7: 1 injection of 1 ml
• Day 14: 1 injection of 1 ml
• Day 28: 1 injection of 1 ml

OrAbbreviated multisite (2-1-1) regimen:

• Day 0: 2 injections each of 1 ml at separate sites
• Day 7: 1 injection of 1 ml
• Day 21:1 injection of 1 ml

Intradermal schedules

: One intradermal (ID) dose is comprised of 0.1 ml.Thai Red Cross (2-2-2-0-1-1) schedule:

• Day 0: 2 injection each of 0.1 ml at separate sites
• Day 3: 2 injection each of 0.1 ml at separate sites
• Day 7: 2 injection each of 0.1 ml at separate sites
• Day 28: 1 injection of 0.1 ml Day 90:1 injection of 0.1 ml (optional).

OrWHO Modified Thai Red Cross (2-2-2-0-2) schedule:

• Day 0: 2 injection each of 0.1 ml at separate sites
• Day 3: 2 injection each of 0.1 ml at separate sites
• Day 7: 2 injection each of 0.1 ml at separate sites
• Day 28: 2 injection each of 0.1 ml at separate sites

In case of severe (WHO category 3) wounds, rabies immunoglobulin should be administered as soon as possible with the first dose of rabies vaccine. The anti-rabies immunoglobulin should be used as local wound soakage injections as much as possible, with the rest part for muscle injection. The rabies vaccine should be administered in different injection site.

Vaccination of immunized subjects: If vaccine administered in less than 5 years of exposure (cell culture rabies vaccine): 2 injections one on each of DO, D3. If vaccine administered in more than 5 years of exposure or incomplete vaccination: 5 injections on DO, D3, D7, D14 and D28 with administration of immunoglobulin if required. Post-exposure vaccination must be administered on the basis of severity under medical supervision.

WHO guidelines on post-exposure treatment depending on wound severity-

Touching or feeding of animal, licks on intact skin:

• Recommended treatment: None, if reliable case history is available.

Nibbling of uncovered skin, minor scratches, superficial bites (except on head, neck, shoulder girdle.arms or hands) or abrasions without bleeding, licks on broken skin:

• Recommended treatment: Administer vaccine immediately on Day 0, D3, D7, D14 and D28.Stop treatment if animal remains healthy throughout the observation period of 10 days or if animal is killed humanely and found to be negative by appropriate laboratory techniques.

Single or multiple transdermal bites or scratches specially on head, neck, shoulder girdle,arms or hands. Contamination of mucus membrane with saliva (i.e. licks on broken skin):

• Recommended treatment: Administer rabies immunoglobulin immediately with the first dose of rabies vaccine. Administer rabies vaccine on Day 0, D3, D7, D14 and D28 or D90 (optional). Stop treatment if animal remains healthy throughout the observation period of 10 days or if animal is killed humanely and found to be negative by appropriate laboratory techniques

Reconstitute with the provided diluent.

Administrations:

• Prompt and gentle thorough washing with soap or detergent and flushing the wound with running tap water for at least 15 minutes.
• After washing, disinfectants like either ethanol (700 ml/l) or tincture or aqueous solution of iodine or povidone iodine must be applied.
• Don’t bandage or suture the wound.

Co-administration

: Corticosteroid and immunosuppressive treatment may interfere with antibody production and cause vaccination failure. In these cases, a titration of neutralizing antibodies should be performed.

পার্শ্বপ্রতিক্রিয়া

Minor local reactions like pain, erythema, oedema, pruritus and induration at the injection site and lasting to 24-48 hours. Moderate fever, shivering, fainting, asthenia, dizziness, respiratory manifestations (dyspnoea, wheezing), fever, abdominal pain, vomiting and allergic skin reactions (urticaria, rash, itching).

সতর্কতা

Precaution:

• Intravenous injection is prohibited.
• The vaccine and anti-rabies immunoglobulin must not be administered with same syringe and in the same injection site.
• Before use, please carefully check package, label, appearance and the validity period.
• After reconstitution, the freeze-dried rabies vaccine should be administered as soon as possible.
• Do not shake during and after reconstitution.

Special precaution for the intradermal route:

• It is essential that intradermal administration of vaccine be administered only by medical staff trained in the ID technique in order to ensure that the vaccine is delivered intradermally and not subcutaneously.
• For the intradermal route a sterile syringe with fixed needle (insulin type) is preferred.
• A sterile needle and syringe must be used to withdraw and administer each dose of vaccine for each patient to avoid cross infection. Correct intradermal injection should result in a raised papule with a orange peel appearance. If the vaccine has been injected too deeply and a papule is not seen, the needle should be withdrawn and re-inserted nearby.
• This vaccine does not contain a preservative, therefore, great care must be taken to avoid contamination of reconstituted vaccine.
• Any reconstituted vaccine should be used as soon as possible. It must be stored in a refrigerator at +2 °C to +8 °C and used within 8 hours after reconstitution or discarded.
• ID route must not be used in the following conditions : Patient receiving immunosuppressive therapies, including irradiation, anti metabolites, alkylating agents, cytotoxic drugs and corticosteroids. Immunocompromised individuals.

মিথস্ক্রিয়া

Concurrent use with immunosuppressants may reduce the efficacy of vaccines.

গর্ভাবস্থাকালীন ব্যবহার

Pregnancy. The potential risk of administration of rabies vaccine during pregnancy is unknown. Due to the severity of the disease, pregnancy is not considered to be a contraindication to post-exposure prophylaxis.

Lactation: It is not known whether the vaccine is excreted in human breast milk. Due to the severity of the disease, breast-feeding is not considered a contraindication.

বৈপরীত্য

Rabies vaccine is contraindicated in the following cases:Pre-exposure-

• Severe fever, febrile infection, acute disease, progressive chronic diseases
• Known hypersensitivity reactions to rabies vaccine or any of its components Post-exposure
• No contraindication to post-exposure treatment, because rabies is lethal disease, any contraindication to exposure, treatment should be considered carefully before disqualifying an individual for anti-rabies treatment.

অতিরিক্ত সতর্কতা

তীব্র ওভারডোজ

অন্যান্য ওষুধের সাথে প্রতিক্রিয়া

সংরক্ষণ

শিশুদের নাগালের বাহিরে রাখুন । +২ - +৮ ডিগ্রী সেলসিয়াস তাপমাত্রায় সংরক্ষণ করুন ।পরিবহনের সময় ও _২-+৮ ডিগ্রী সেলসিয়াস তাপমাত্রা থাকতে হবে । আলো হতে রক্ষা করুন । যেন জমে না যায় ।