জোনেস্টা

Zaleplon, a pyrazolopyrimidine, is a sedative and hypnotic agent structurally unrelated to the benzodiazepines and other sedative-hypnotic agents. It is shown to interact with GABA subtype A complex by binding selectively to benzodiazepine type 1 receptor. It reduces sleep latency without affecting sleep duration.

ব্যবহার

জোনেস্টা অনিদ্রার স্বল্পমেয়াদী চিকিৎসার জন্য নির্দেশিত । জোনেস্টা নিয়ন্ত্রিত ক্লিনিক্যাল ট্রায়ালগুলিতে 30 দিন পর্যন্ত ঘুমানোর সময় কমিয়ে দেখানো হয়েছে।

জোনেস্টা এর দাম কত? জোনেস্টা এর দাম

সুচিপত্র

• জোনেস্টা
• কাজ
• খাওয়ার নিয়ম
• পার্শ্বপ্রতিক্রিয়া
• সতর্কতা
• মিথস্ক্রিয়া
• গর্ভাবস্থাকালীন ব্যবহার
• তীব্র ওভারডোজ
• অন্যান্য ওষুধের সাথে প্রতিক্রিয়া
• বৈপরীত্য
• সংরক্ষণ

খাওয়ার নিয়ম / ব্যবহারের নিয়ম

জোনেস্টা খাওয়ার নিয়ম / ব্যবহারের নিয়ম

The dose of Zaleplon should be individualized. The recommended dose of Zaleplon for most non elderly adults is 10 mg. For certain low weight individuals, 5 mg may be a sufficient dose. Although the risk of certain adverse events associated with the use of Zaleplon appears to be dose dependent, the 20 mg dose has been shown to be adequately tolerated and may be considered for occasional patient who does not benefit from a trial of lower dose. Dosage above 20 mg has not been adequately evaluated and is not recommended.Zaleplon should be taken immediately before bedtime. Taking Zaleplon with or immediately after a heavy, high fat meal results in slower absorption and would be expected to reduce the effect of Zaleplon on sleep latency. Elderly patients and debilitated patients appear to be more sensitive to the effects of hypnotic, and respond to 5 mg of Zaleplon. The recommended dose for these patients is therefore 5 mg, doses over 10 mg are not recommended. For patients with mild to moderate renal impairment no dose adjustment is necessary.An initial dose of 5 mg should be given to patients concomitantly taking Cimetidine because ZalZaleplon clearance is reduced in this population.

পার্শ্বপ্রতিক্রিয়া

Side effects of Zaleplon appear to be dose related. So, it is important to use the lowest possible effective dose, specially in the elderly. The side effects are usually mild and transient, the most common are diarrhoea, nausea, vomiting, vertigo, headache, asthenia, nightmare etc.

সতর্কতা

Timing of drug administration: Zaleplon should be taken immediately before bedtime or after the patient has gone to bed.Use in the elderly and/or debilitated patients: Impaired motor and/or cognitive performance after repeated exposure or unusual sensitivity to sedative/hypnotic drugs is a concern in the treatment of elderly and/or debilitated patients. A dose of 5 mg is recommended for elderly patients to decrease the possibility of side effects. Elderly and/or debilitated patients should be monitored closely.Use in patients with concomitant illness: Zaleplon should be used with caution in patients with diseases or conditions that could affect metabolism or haemodynamic responses. Although preliminary studies did not reveal respiratory depressant effects at hypnotic doses of Zaleplon in normal subjects, caution should be observed if Zaleplon is prescribed to patients with compromised respiratory function, because sedative/hypnotic have the capacity to depress respiratory drive. However, patients with compromised respiration due to preexisting illness should be monitored carefully. The dose of Zaleplon should be reduced to 5 mg in patients with mild to moderate hepatic impairment. It is not recommended for use in patients with severe hepatic impairment.Renal impairment patients: No dose adjustment is necessary in patients with mild to moderate renal impairment. Zaleplon has not been adequately studied in patients with severe renal impairment.Use in patients with depression: As with other sedative or hypnotic drugs, Zaleplon should be administered with caution to patients exhibiting signs or symptoms of depression

মিথস্ক্রিয়া

Zaleplon has been shown to have minimal effects on the kinetic of Warfarin, Imipramine, Ethanol, Ibuprofen, Diphenhydramine, Thioridazine, and Digoxin.

গর্ভাবস্থাকালীন ব্যবহার

Pregnancy: There are no studies of Zaleplon in pregnant women; therefore, it is not recommended for use in women during pregnancy. Zaleplon has no established use in labour and delivery.Lactation: A study in lactating mothers indicated that the clearance and half-life of Zaleplon is similar to that in young normal subjects. A small amount of Zaleplon is excreted in breast milk, with the highest excreted amount occurring during a feeding at approximately 1 hour after Zaleplon administration. Since the small amount of the drug from breast milk may result in potentially important concentrations in infants, and because the effects of Zaleplon on a nursing infant are not known, it is not recommended in nursing mothers.

বৈপরীত্য

Zaleplon is contraindicated in patients with known hypersensitivity to any of its components.

অতিরিক্ত সতর্কতা

বিশেষ রোগী গোষ্ঠী: সিমেটিডিনে রোগীদের শয়নকালীন হেপাটিক প্রতিবন্ধকতায় প্রাথমিকভাবে 5 মিলিগ্রাম ডোজ পাওয়া উচিত:

হালকা থেকে মাঝারি: শোবার সময় 5 মিলিগ্রাম।

গুরুতর: বিপরীত।

পেডিয়াট্রিক ব্যবহার : পেডিয়াট্রিক রোগীদের মধ্যে জোনেস্টা এর সুরক্ষা এবং কার্যকারিতা প্রতিষ্ঠিত হয়নি।

তীব্র ওভারডোজ

অন্যান্য ওষুধের সাথে প্রতিক্রিয়া

সংরক্ষণ